Starting with UFC on ABC: Holloway vs. Kattar, a limited number of fans were allowed inside the newly built Etihad Arena, marking the first time since UFC 248 on March 7, 2020 that non-essential event personnel were in attendance.[5] The venue has maximum capacity of over 18,000, but the UFC was expecting to have closer to 2,000 fans for each of the Fight Island's events during the week.[6]
For the event to be broadcast live during Prime time hours on the east coast of North America, the main card began at 7:00 am (January 24) local time in Abu Dhabi, with a full preliminary card beginning at approximately 4:00 am Gulf Standard Time.[7]
After defending his lightweight title at UFC 254 in October, Khabib Nurmagomedov immediately announced his retirement, citing his father's death from complications related to COVID-19 in last July as the main reason behind it.[11] Despite his announcement, the title was never officially vacated as UFC President Dana White said several times that he believed Nurmagomedov would still fight again.[12][13][14] A meeting between both of them to discuss the champion's future was then expected to happen this week during the organization's stint at Fight Island, eventually taking place on January 15.[15][16] The following day, White made an appearance live on ABC during the main card of UFC on ABC: Holloway vs. Kattar and revealed the outcome of the meeting: the Russian left the door open to a potential return, depending on how the main and co-main event fighters perform at this event, while also praising Charles Oliveira's performance at UFC 256.[17][18] Despite White's announcement, Nurmagomedov indicated in another interview that "fighting again is not in my plans".[19]
A bantamweight bout between promotional newcomers Umar Nurmagomedov and Sergey Morozov was initially scheduled to take place at UFC 254, but Nurmagomedov pulled out due to an illness.[20] The pairing was then rescheduled for this event.[21] Finally, the bout was set to take place 3 days prior at UFC on ESPN: Chiesa vs. Magny.[22]
A flyweight bout between Amir Albazi and Zhalgas Zhumagulov was expected to take place at UFC on ESPN: Smith vs. Clark, but Zhumagulov pulled out due to visa issues and the bout was rescheduled for this event.[23][24]
Tagir Ulanbekov was briefly scheduled to face returning veteran Matheus Nicolau in a flyweight bout.[28] However, Ulanbekov withdrew in late December due to undisclosed reasons.[29] The pairing was eventually rescheduled for UFC Fight Night: Edwards vs. Chimaev on March 13.[30]
A featherweight bout between Shane Burgos and Hakeem Dawodu was scheduled for the event.[35] However on January 9, Dawodu was forced to withdraw from the bout citing a shoulder injury.[36] The UFC confirmed three days later that Burgos was also injured and the bout was canceled.[37]
On the day of the weigh-ins, a couple of lightweight bouts suffered major changes due to several issues: Ottman Azaitar and Matt Frevola were scheduled to meet in the preliminary portion of the event.[38] However, it was announced that Azaitar was pulled from the bout and had his contract terminated after it was determined that he had violated COVID-19 health and safety protocols, as he attempted to help others enter the UFC's designated safety zone.[39] The other bout that suffered alterations featured Nasrat Haqparast and Arman Tsarukyan.[40] Haqparast withdrew from the bout due to an undisclosed illness and Tsarukyan weighed in at 157 pounds, one pound over the lightweight non-title fight limit.[41][42] As a result, the promotion arranged a catchweight bout between Frevola and Tsarukyan to keep both athletes on the card.[43][44] Subsequently, Tsarukyan forfeited 20% of his purse to Frevola as a result of missing weight.[45]